Wang Menglin, a woman from Nanjing, is 32 years old this year, but she has already been marriedcancerThe conflict lasted for 18 years. She was diagnosed with osteosarcoma when she was 14, and her second primary cancer, breast cancer, was diagnosed in 2015. In recent years, a new primary cancer has been detected every year, and currently five cancers have been diagnosed.Wang Menglin said, “With theseTumorAfter 18 years of “falling in love and killing each other”, I’m no longer as timid as I used to be. With the support and encouragement of my husband, family and friends, I can regain my confidence. “However, as an extremely rare patient with multiple primary cancers, she felt very confused and hoped to find a comprehensive solution.
Xinyu News reported that Wang Menglin was born in Nanjing in 1991. When she was 14 years old, her left hand accidentally hit the railing of a lecture theatre. The hit area began to swell after a few days and did not improve. she gone. Hospital after a month. X-rays were taken and it was revealed that the bone was disintegrated and he needed to be immediately hospitalized.
After a series of examinations, it was eventually determined that it might be malignant osteosarcoma. After chemotherapy and surgery, the left arm was saved, but the ulnar bone was removed. After two courses of chemotherapy, another repair surgery was performed in 2009.
It is reported that Wang Menglin survived the five-year crisis period safely, but in 2015, a lump was discovered in her left breast during a physical examination. She was later diagnosed with bilateral breast cancer and had both breasts removed. She had breast reconstruction surgery, implants and life seemed to be settling down.
The peaceful days lasted only 5 years. In 2021, during a re-examination at the hospital, it was revealed that a lump in Wang Menglin’s lung was much larger than previously thought. The doctor suspected it was early stage lung cancer. “At that time, I was pulled into the abyss again. I was wondering why I had such a disease. Cancer? I usually eat healthy and don’t stay up late or drink alcohol. The only possibility is that it There’s a genetic problem.”
Wang Menglin was not the only cancer patient in her family. His father was diagnosed with gastric cancer in 2009 and later lung cancer and soft tissue tumors. Ultimately, she died at the age of 56 in late 2018. Because both father and daughter were suffering from different primary cancers, during Wang Menglin’s father’s treatment, a genetic company conducted genetic research on three generations of her grandparents. Tested.SearchIt was found that her grandfather’s genes were normal, but her father’s genes contained a TP53 mutation, which was passed on to her.
According to reports, TP53 gene is a very important tumor suppressor gene in humans. It is also known as the “guardian gene” or “gatekeeper of the genome” and plays a role in monitoring and regulating genome stability in cells. Mutations or variations in the TP53 gene may lose the ability to suppress tumor cells and increase the risk of cancer.
After anxiously waiting for half a month, Wang Menglin underwent surgery to remove a lobe of his left upper lung and was diagnosed with early-stage lung adenocarcinoma.
I went to the hospital for review in early September 2022 and found new lumps in my lungs, more than 10 of them. This time she was very calm, but her boyfriend cried extremely sad, “We met in 2011, I received the certificate after my breast cancer surgery in 2015, and we held a replacement wedding in 2020. She has gone through many painful and Has been with me in difficult situations.” Difficult moments. Bearing in mind that I haven’t had children due to physical reasons, and if I have another child, I’m afraid there will be a risk of passing it on to the next generation.”
China
